Multi-parametric high-throughput analysis of hepatotoxicity using a 3D primary liver cell culture model

3D cell cultures offer a more physiologically relevant option, but there are currently only a few high throughput screening (HTS) 3D systems that have high consistency and easily allow integration with downstream analysis methods. In this application note, we demonstrate the creation of an advanced 3D primary human hepatocyte (PHH) model using the RASTRUM platform that seamlessly integrates with Revvity’s HTS technologies.